Includes bibliographical references and index.
|Statement||edited by Majambu Mbikay, Nabil G. Seidah|
|Series||Methods in molecular biology -- 768, Springer protocols, Methods in molecular biology (Clifton, N.J.) -- v. 768., Springer protocols|
|The Physical Object|
|Pagination||xi, 367 p. :|
|Number of Pages||367|
|LC Control Number||2011933260|
Proprotein Convertases in Gynecological Cancers - Ebook written by Andres J.P. Klein-Szanto, Jirong Zhang, Daniel Bassi. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read Proprotein Convertases in Gynecological Cancers. Meticulous and up-to-date, Proprotein Convertases represents an instructive and useful reference book for all scientists interested in endoproteolytic activation and/or inactivation of secretory proproteins through limited proteolysis, for experts in the field and newcomers to it as well. Meticulous and up-to-date, Proprotein Convertases represents an instructive and useful reference book for all scientists interested in endoproteolytic activation and\/or inactivation of secretory proproteins through limited proteolysis. Abstract. The proprotein convertases (PCs) are secretory mammalian serine proteinases related to bacterial subtilisin-like enzymes. The family of PCs comprises nine members, PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9 (Fig. ).While the first seven PCs cleave after single or paired basic residues, the last two cleave at non-basic residues and the last one PCSK9 only.
Processing of VEGF-C and -D by the Proprotein Convertases: Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis (Colloquium Protein Activation and Cancer): Medicine & Health Science Books @ The proprotein convertase PC2, one of the earliest convertases to evolve, plays an integral role in peptidergic signaling in organisms as diverse as flies and humans. More recent studies have elaborated the intricate interplay of PC2 and its binding protein 7B2 and suggest that there are unusual points of regulation for this enzyme in the. Proprotein convertases in intercellular communication leading to inflammation and tumor progression The tumor microenvironment (TME) is a complex system including tumor cells, epithelial cells and stromal cells composed of immune cells, fibroblasts, endothelial cells, adipocytes, the extracellular matrix and others [ 34 ]. Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is an enzyme that in humans is encoded by the PCSK1 gene. PCSK1 and PCSK2 differentially cleave proopiomelanocortin and they act together to process proinsulin and proglucagon in pancreatic islets.
Get this from a library! The proprotein convertases: discovery, characteristics, and link to tumor progression and metastasis. [A-Majid Khatib] -- Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the. 1 8 e book isbn 13 1 6 e book convertases are widely expressed activating enzymes involved in various physiological and pathological processes the purpose of this book is to proprotein convertases pcs a new potential strategy in cancer therapy read books reviews amazoncom. by the Proprotein Convertases: Importance in Angiogenesis, This e-book is an original work commissioned for the Colloquium Digital Library of Life Sciences, a curated collection of time-saving pedagogical resources for researchers and students who want to quickly get up to speed in a new area of life science/biomedical research. Each e-book. Background: The mammalian proprotein convertases (PCs) constitute a family of nine secretory serine proteases related to bacterial subtilisin and yeast kexin. Seven of them (PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7) activate cellular and pathogen precursor proteins by cleavage at single or paired basic residues, while SKI-1/S1P and PCSK9 regulate cholesterol/lipid homeostasis via cleavage.